{"id":106834,"date":"2021-02-11T16:52:15","date_gmt":"2021-02-11T16:52:15","guid":{"rendered":"https:\/\/fin2me.com\/?p=106834"},"modified":"2021-02-11T16:52:15","modified_gmt":"2021-02-11T16:52:15","slug":"roches-tocilizumab-cuts-deaths-in-hospitalised-covid-19-patients-study","status":"publish","type":"post","link":"https:\/\/fin2me.com\/markets\/roches-tocilizumab-cuts-deaths-in-hospitalised-covid-19-patients-study\/","title":{"rendered":"Roche's tocilizumab cuts deaths in hospitalised COVID-19 patients – study"},"content":{"rendered":"

LONDON (Reuters) – Roche\u2019s arthritis drug tocilizumab cuts the risk of death among patients hospitalised with severe COVID-19, also shortening the time to recovery and reducing the need for mechanical ventilation, results of a large trial showed on Thursday.<\/p>

FILE PHOTO: A pharmacist displays a box of tocilizumab, which is used in the treatment of rheumatoid arthritis, at the pharmacy of Cambrai hospital, France, April 28, 2020. REUTERS\/Pascal Rossignol\/File Photo<\/figcaption>

The findings – from the RECOVERY trial, which has been testing a range of potential treatments for COVID-19 since March 2020 – should help clear up confusion about whether tocilizumab has any benefit for COVID-19 patients after a slew of recent mixed trial results.<\/p>\n

\u201cWe now know that the benefits of tocilizumab extend to all COVID patients with low oxygen levels and significant inflammation,\u201d said Peter Horby, a professor of emerging infectious diseases at Oxford University and the joint lead investigator on the RECOVERY trial.<\/p>\n

In June last year, the RECOVERY trial found that the cheap and widely available steroid dexamethasone reduced death rates by around a third among the most severely ill COVID-19 patients. That drug has since rapidly became part of standard-of-care recommended for severe patients.<\/p>\n

Tocilizumab, sold under the brand name Actemra, is an intravenous anti-inflammatory monoclonal antibody drug used to treat rheumatoid arthritis. It was added to the trial in April 2020 for patients with COVID-19 who required oxygen and had evidence of inflammation.<\/p>\n

The study data were from 2,022 COVID-19 patients who were randomly allocated to receive tocilizumab by intravenous infusion and who were compared with 2,094 patients randomly allocated to usual care alone. Researchers said 82% of all patients were taking a systemic steroid such as dexamethasone.<\/p>\n

Results showed that treatment with tocilizumab significantly reduced deaths – with 596 (29%) of the patients in the tocilizumab group dying within 28 days, compared with 694 (33%) patients in the usual care group.<\/p>\n

This translates to an absolute difference of 4% and means that for every 25 patients treated with tocilizumab, one additional life would be saved, Horby and his co-lead investigator Martin Landray said.<\/p>\n

They added that benefits of tocilizumab were clearly seen to be in addition to those of steroids.<\/p>\n

\u201cUsed in combination, the impact is substantial,\u201d said Landray, who is also an Oxford professor of medicine and epidemiology.<\/p>\n

He added that results \u201cclearly show the benefits of tocilizumab and dexamethasone in tackling the worst consequences of COVID-19 \u2013 improving survival, shortening hospital stay, and reducing the need for mechanical ventilators.\u201d<\/p>\n

Roche\u2019s drug division chief Bill Anderson said last week that previous mixed results were likely due to differences in the type of patients studied, when they were treated, and the endpoint – the juncture at which success or failure is measured.<\/p>\n

\u201cWe think we\u2019re sort of zooming in on both the most relevant endpoints and relevant patient population,\u201d Anderson said. \u201cIt seems like the ideal candidates are patients who are really in that acute phase of inflammatory attack.\u201d<\/p>\n

Actemra, along with Sanofi\u2019s similar drug Kevzara, was authorized by Britain\u2019s NHS in early January for COVID-19 patients in intensive care units after preliminary data from a smaller study called REMAP-CAP indicated it could reduce hospital stays by about 10 days.<\/p>\n

During 2020, Actemra rose to become Roche\u2019s fifth-best-selling drug, at more than $3 billion, with nearly $600 million from COVID-19 treatment.<\/p>\n

Source: Read Full Article<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

LONDON (Reuters) – Roche\u2019s arthritis drug tocilizumab cuts the risk of death among patients hospitalised with severe COVID-19, also shortening the time to recovery and […]<\/p>\n","protected":false},"author":3,"featured_media":106833,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"yoast_head":"\nRoche's tocilizumab cuts deaths in hospitalised COVID-19 patients - study - Fin2me<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fin2me.com\/markets\/roches-tocilizumab-cuts-deaths-in-hospitalised-covid-19-patients-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Roche's tocilizumab cuts deaths in hospitalised COVID-19 patients - study - Fin2me\" \/>\n<meta property=\"og:description\" content=\"LONDON (Reuters) – Roche\u2019s arthritis drug tocilizumab cuts the risk of death among patients hospitalised with severe COVID-19, also shortening the time to recovery and [...]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fin2me.com\/markets\/roches-tocilizumab-cuts-deaths-in-hospitalised-covid-19-patients-study\/\" \/>\n<meta property=\"og:site_name\" content=\"Fin2me\" \/>\n<meta property=\"article:published_time\" content=\"2021-02-11T16:52:15+00:00\" \/>\n<meta name=\"author\" content=\"Mark\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/fin2me.com\/wp-content\/uploads\/2021\/02\/cnewsfotor18.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Mark\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/fin2me.com\/markets\/roches-tocilizumab-cuts-deaths-in-hospitalised-covid-19-patients-study\/\",\"url\":\"https:\/\/fin2me.com\/markets\/roches-tocilizumab-cuts-deaths-in-hospitalised-covid-19-patients-study\/\",\"name\":\"Roche's tocilizumab cuts deaths in hospitalised COVID-19 patients - 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