{"id":134996,"date":"2023-12-06T15:39:17","date_gmt":"2023-12-06T15:39:17","guid":{"rendered":"https:\/\/fin2me.com\/?p=134996"},"modified":"2023-12-06T15:39:17","modified_gmt":"2023-12-06T15:39:17","slug":"syros-presents-positive-phase-2-trial-data-of-tamibarotene-combination-stock-up-in-premarket","status":"publish","type":"post","link":"https:\/\/fin2me.com\/markets\/syros-presents-positive-phase-2-trial-data-of-tamibarotene-combination-stock-up-in-premarket\/","title":{"rendered":"Syros Presents Positive Phase 2 Trial Data Of Tamibarotene Combination: Stock Up In Premarket"},"content":{"rendered":"
Syros Pharmaceuticals (SYRS) announced Wednesday positive initial data from its ongoing SELECT-AML-1 Phase 2 trial evaluating tamibarotene, in combination with venetoclax and azacitidine in newly diagnosed, unfit patients with acute myeloid leukemia or AML and RARA gene overexpression.<\/p>\n
In pre-market activity on Nasdaq, the shares were gaining around 10 percent to trade at $3.09.<\/p>\n
Tamibarotene is an oral, selective, retinoic acid receptor alpha or RAR agonist. Syros continues to enroll patients in SELECT-AML-1 and anticipates reporting updated data from the trial in 2024.<\/p>\n
The company noted that SELECT-AML-1 is evaluating the safety and efficacy of tamibarotene in combination with venetoclax and azacitidine compared to venetoclax and azacitidine in approximately 80 patients randomized 1:1.<\/p>\n
The trial is also evaluating the triplet regimen as a salvage strategy in patients in the control arm who do not respond to venetoclax and azacitidine. The primary endpoint of the trial is complete response rateor CR \/complete response with incomplete hematologic recovery or Cri.<\/p>\n
In December 2022, Syros reported data from the safety lead-in portion of SELECT-AML-1, in which five of six response evaluable patients achieved CR\/CRi.<\/p>\n
Thomas Cluzeau, Head of Hematology at Nice University Hospital, Cte d’Azur University in France, said, “Despite the recent advances in treatment for unfit AML patients, there remains a substantial need for options that offer higher response rates and improved overall survival, particularly for the one-third of patients who do not respond to existing standard-of-care. I believe tamibarotene may offer a significant therapeutic advance for the treatment of AML and I am eager to continue enrolling patients in the ongoing SELECT-AML-1 trial.”<\/p>\n
For More Such Health News, visit rttnews.com <\/p>\n